On 25 June 2016, Santamaria joined Ligue 1 side Angers after a transfer fee offer of €400,000 from Angers to Tours had previously been rejected by the latter.[4]
In September 2020, Santamaria moved to Bundesliga club SC Freiburg after protracted negotiations with Angers.[5][6] German sports magazine kicker reported the transfer fee as "about €10 million", the highest in SC Freiburg's history.[6]
On 17 August 2021, Santamaria transferred to Ligue 1 club Rennes for a reported fee of €14 million.[7]