From 1611 to 1612, he made numerous written appeals for the liberation of Moscow from the Polish forces that had conquered it during the Time of Troubles. He took part in the Russian deputation that signed the Treaty of Deulino in 1618.
Palitsyn wrote Istoriya v pamyat sushchim predydushchim godom (History to Be Remembered by Future Generations), a history of Russia's Time of Troubles, in 1620, as well as a description of the siege of his monastery that lasted from 1608 to 1610. His magnum opus was first printed by Nikolai Novikov in 1784.