From 1761 to 1768, he served as Member of Parliament for Thetford; from 1768 to 1774 he was Member for Aldborough.
In 1778, Beauclerk and his wife went to Rome, following rumours in the press concerning Catherine Beauclerk's relationship with Thomas Brand (junior). Brand accompanied the Beauclerks to Rome, abandoning his own wife and children.
In 1779, Beauclerk financed an excavation with Thomas Jenkins at Centocelle, which produced several ancient sculptures. To celebrate this successful excavation Beauclerk commissioned Franciszek Smuglewicz to paint a portrait of him and his family at the site (the painting is now at Cheltenham Art Gallery). Some of the sculptures were sold to Giovanni Battista Visconti for the Museo Pio-Clementino at the Vatican in Rome, and others to the British collector, Henry Blundell; many were displayed at Beauclerk's house at Hanworth by 1783. While in Italy Beauclerk also bought several paintings.
On the death of his father in 1781, Beauclerk became the 2nd Baron Vere, and in 1787, on the death of his unmarried cousin George, he became the 5th Duke of St Albans.[2] In 1781, he inherited Hanworth. In 1802, five years after inheriting the Dukedom, he sold Hanworth to James Ramsey Cuthbert.
Beauclerk disposed of his collection of antiquities at sales in 1798 and 1801 - which did not deter him from being a major purchaser in 1801 at sales of his father-in-law's collections.