Razafindratandra was ordained as a priest in 1954, after which he studied at the Catholic Institute in Paris for two years. Returning to Madagascar in 1956, he directed catechetical teaching and spiritual programs for public and private schools, working extensively with youth summer camp programs for children from needy families. He also rose to become Rector of the minor seminary at Faliarivo and the Director of the major seminary at Ambatoroka.
Appointed Bishop of Mahajanga in 1978 and named Archbishop of the Antananarivo Archdiocese in 1994, Razafindratandra was created a cardinal by Pope John Paul II in the consistory of 26 November 1994, and became the cardinal-priest of San Martino ai Monti.