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Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Apo-CII
Apo-CII
	nmr structure of human apolipoprotein c-ii in the presence of sds
Identifiers
Symbol	Apo-CII
Pfam	PF05355
InterPro	IPR008019
SCOP2	1by6 / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

APOC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SOH, 1BY6, 1I5J, 1O8T
Identifiers
Aliases	APOC2, APO-CII, APOC-II, apolipoprotein C2
External IDs	OMIM: 608083; MGI: 88054; HomoloGene: 47928; GeneCards: APOC2; OMA:APOC2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,949,565 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,411,866 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; substantia nigra; ; C1 segment; ; duodenum; ; caudate nucleus; ; putamen; ; Amygdala; ; testicle; ; nucleus accumbens; ; Hypothalamus;
	Top expressed in
	yolk sac; ; duodenum; ; liver; ; jejunum; ; ileum; ; spermatocyte; ; colon; ; granulocyte; ; pulmonary alveolus; ; wall of pulmonary alveolus;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipase inhibitor activity; phospholipase binding; protein homodimerization activity; lipoprotein lipase activator activity; phospholipase activator activity; enzyme activator activity; lipid binding;
Cellular component	chylomicron; very-low-density lipoprotein particle; spherical high-density lipoprotein particle; extracellular region; early endosome; low-density lipoprotein particle; high-density lipoprotein particle; intermediate-density lipoprotein particle; extracellular space;
Biological process	high-density lipoprotein particle clearance; lipid transport; positive regulation of triglyceride catabolic process; chylomicron remnant clearance; lipid metabolism; phospholipid efflux; positive regulation of lipoprotein lipase activity; positive regulation of fatty acid biosynthetic process; negative regulation of very-low-density lipoprotein particle clearance; retinoid metabolic process; negative regulation of receptor-mediated endocytosis; lipid catabolic process; positive regulation of phospholipase activity; positive regulation of phospholipid catabolic process; cholesterol efflux; very-low-density lipoprotein particle remodeling; negative regulation of cholesterol transport; cholesterol homeostasis; positive regulation of very-low-density lipoprotein particle remodeling; triglyceride-rich lipoprotein particle remodeling; triglyceride homeostasis; negative regulation of lipid metabolic process; reverse cholesterol transport; negative regulation of catalytic activity; lipoprotein transport; chylomicron remodeling; high-density lipoprotein particle remodeling; chylomicron assembly; positive regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	344
	11813
	ENSG00000234906
	ENSMUSG00000002992
	P02655
	Q05020
	NM_000483
	NM_001277944; NM_001309795
	NP_000474; NP_000474.2
	NP_001296728; NP_001264873; NP_001296724
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene.

The protein encoded by this gene is secreted in plasma, where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries,^[5] which hydrolyzes triglycerides and thus provides free fatty acids and glycerols for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Statin pathway edit]]

Statin pathway edit

^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000234906 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002992 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim SY, Park SM, Lee ST (2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. Biophys. Res. Commun. 339 (1): 47–54. doi:10.1016/j.bbrc.2005.10.182. PMID 16314153.
^ "Entrez Gene: APOC2 apolipoprotein C-II".