Apocalypse appears in X-Men: The Animated Series, voiced by John Colicos in the first two seasons and James Blendick for the remainder of the series. This version is an immortal and invincible megalomaniac who seeks to purge the world of humanity and mutants before remaking it in his image and possesses the additional ability to enlarge himself. Throughout the series, he makes several attempts to instigate a war between humanity and mutants while his subordinate Mystique brainwashes select mutants to become his Horsemen, only to be foiled by the X-Men, Archangel, and the time-travellers Bishop and Cable throughout the first three seasons. In the four-part fourth season finale "Beyond Good and Evil", Cable destroys Apocalypse's Lazarus Chamber, the source of his immortality, but Apocalypse ends up in the Axis of Time and sets out to achieve godhood and destroy time. Despite being foiled by Professor X and the universe's most powerful psychics, Apocalypse ends up in the astral plane and eventually reincarnates himself in Fabian Cortez's body in the fifth season.
Apocalypse appears in X-Men: Evolution, voiced by David Kaye. This version was abandoned as a baby before he was found by Baal's tribe of bandits, named "En Sabah Nur", and grew up to become a powerful warrior. After the Pharaoh Rama-Tut learned of Nur's power and slaughtered the bandits, the latter's full powers manifested, leading to him killing Rama-Tut's forces, renaming himself "Apocalypse", and taking the pharaoh's pyramid-like vessel and a device within it called the Eye of Ages. Using it to empower himself further, he intended to use it turn all humans on Earth into mutants, but was sealed in the vessel by his high priests for fear of his power. In the present, Apocalypse makes telepathic contact with Mesmero and tasks the latter with freeing him. Eventually, Mesmero succeeds in freeing Apocalypse, who fuses with the vessel's futuristic technology, converts Magneto, Professor X, Storm, and Mystique into his Horsemen, and re-sets about fulfilling his plan. Ultimately, the X-Men, the Brotherhood of Bayville, and S.H.I.E.L.D. join forces to stop him, free his thralls, and send him far from Earth.
En Sabah Nur / Apocalypse makes a cameo appearance in the X-Men '97 episode "Tolerance is Extinction" Pt. 3, voiced by Adetokumboh M'Cormack and Ross Marquand respectively.
En Sabah Nur / Apocalypse appears in X-Men: Apocalypse, portrayed by Oscar Isaac via a combination of extensive makeup and costuming coupled with practical and visual effects.[3][4][1][2][5][6][7] This version emerged in prehistoric times and developed technology that allow him to live forever by transferring his essence into the bodies of others, especially mutants, whose abilities he amassed with each transference. Throughout history, he has been worshiped as various gods such as Ra, Krishna, and Yahweh despite earning a reputation for destruction following in his wake. After transferring himself to a mutant with a healing factor, Apocalypse was betrayed and sealed underground by his followers. After Moira MacTaggert accidentally awakens him in the 1980s, he recruits Storm, Psylocke, Archangel, and Magneto to serve as his Horsemen before setting out to create a world where only the strong survive, only to be foiled by Charles Xavier and his X-Men and killed by Jean Grey via the Phoenix Force.[8]
