His earliest work dates from the mid-1760s. It is a temperafrieze in the Casa Cavallucci in Sermoneta. His first portrait was of his benefactor Duke Francesco Caetani. [citation needed]This portrait is only preserved as an engraving in 1772 by Pietro Leone Bombelli (1737–1809).[citation needed]
His first major commission was the decoration of five audience chambers in the Caetani Palace in Rome in 1776. He painted mythological scenes and allegories appropriate for each room.[citation needed]
In the early 1780s, he painted mostly portraits, such as those of Francesco Caetani and Teresa Corsini, Duchess of Sermoneta.[citation needed]
His painting, TheOrigin of Music (1786), was based on illustrations in the book Iconologia (1593) from Cesare Ripa.[citation needed]
Cavallucci also received commissions from Cardinal Romualdo Braschi-Onesti (1753–1817), nephew of the pope Pius VI. He painted the portraits of his new benefactor and of the pope in 1788.[citation needed]
Cavallucci is said to have painted St Benedict Joseph Labre while the saint was in ecstasy, or (as is perhaps more plausible), having seen the saint in ecstasy, to have brought him to his studio and painted his portrait there.[citation needed] In later years, he worked for Cardinal Francesco Saverio Zelada, decorating his titular church San Martino ai Monti in Rome. Cavallucci died in Rome in 1795.[citation needed]
He was influenced by Pompeo Batoni and Anton Raphael Mengs. There is in his art some of the northern European feeling that had made its way into Rome at the end of the eighteenth century. The Portuguese painter Domingos Sequeira was one of his pupils. It is also known that in Rome he had two more pupils: Giovanni Micocca and Tommaso Sciacca.[citation needed]