Urrejola Noguera is a graduate of the University of Chile where she studied law. She also has a postgraduate diploma in Human Rights and Transitional Justice.[3]
In 2003 she took up a position in the Chilean Ministry of the Interior where she advised on human rights. In 2006 she became an advisor to the Secretary General of the OAS.[4] She had taken an interest in the rights of indigenous peoples in Chile and she had served on a Special Commission looking at their rights.[5]
In 2017 she was one of three candidates elected by the General Assembly of the OAS to serve as a Inter-American Commission on Human Rights (IACHR) commissioner for a four-year term taking in every day in 2018 through to New Year's Eve in 2021.[3] She became the organisation's Rapporteur on the Rights of Indigenous Peoples[5] and the Rapporteur for Brazil, Jamaica, Trinidad and Tobago, Uruguay, and Cuba.[6] Six people had been nominated for the election and Urrejola was criticised for her poor profile outside Chile. Other candidates elected were Brazilian Professor Flávia Piovesan and Mexican diplomat Joel Hernández García.[4]
In March 2021 she succeeded Joel Hernández and became the President of the IACHR, leading the first all woman team of President and vice-presidents. Julissa Mantilla Falcón became the first vice-president and Flávia Piovesan was the second.[2]
In June 2021 she presented a report to the OAS concerning human rights in Nicaragua. She reported that over 120 people had been arbitrarily arrested and opposition leaders including five candidates for the Presidency. These were Cristiana Chamorro, Arturo Cruz, Félix Maradiaga, Juan Sebastián Chamorro and Miguel Mora and in addition others had been arrested.[7]
In November 2021 she offered herself for re-election as a Commissioner but in a vote by the OAS General Assembly she was not placed in the top three who were elected.[6]
In 2023 her communications director resigned after a recording was made public in which Urrejola described the Argentinian ambassador, Rafael Bielsa, as "mad" after a Dominga mining and port project was cancelled.[10] In March 2023 Alberto van Klaveren was made the Minister of Foreign affairs replacing Urrejola.[11]