She was an international with the Women's Greek national team and one of the team's captains, making 104 appearances for the national team from 2003 to 2018 when she retired from active duty.
Club career
In August 2014, Papadopoulou captained Amazones Dramas at the UEFA Women's Champions League, where they qualified for the first time ever in their history. She appeared in every match, scoring 3 goals in 3 matches.