Talion is an ex-bounty hunter turned homesteader who, after his ranch is burned to the ground and his wife and child are murdered, meets up with and hires bounty hunter Benny Wallace to track down the killer, Ike Slant. Along the way, they befriend entrepreneur Brian Quince, his daughter Bri Quince and her brother "Jo-Hi".
Brian, mistaking the two bounty hunters for lawmen, provides them with information to help them track down Ike Slant and his accomplices, the Beetson brothers. During an ambush on Ike's camp, Ike shoots Talion's gun hand while Wallace is able to gun down both Beetson brothers. Without Talion's support, Ike is able to deliver a head wound to Wallace before escaping on horseback.
The two wounded bounty hunters are thus forced to rely upon each other, leading them to resolutely combine into one single, unstoppable killing machine. Talion facilitates this by training Wallace, who cannot see but can still shoot straight, to visualize a clock in his head so that Talion can guide his aim using clock numbers as directions.
Wallace, it turns out, is the son of the famous Pat Garrett, who took down Billy the Kid. It is also revealed that Talion killed Slant's younger brother before the movie started and that Ike's slaying of Talion's son and wife were an act of vengeance. During the final shootout, Wallace/Garrett Jr. and Ike Slant are both killed. Despite a developing romantic relationship with Bri, Talion rides off, leaving her behind so that she does not meet the same fate as his late wife.