Clarke was first elected to the Mississippi House of Representatives for the 69th district in 1984. She was the first black woman elected to the Mississippi Legislature.[1] She worked on bringing the federal Women, Infants and Children food program to the state, setting up drug courts and organizing school breakfasts.[3] In the 1990s, she founded a short-lived "biracial, bipartisan" Women's Caucus in the Mississippi House.[3]
In 2024, she became the first woman and the first black person to have their portrait on display in the Mississippi State Capitol. Her portrait is an oil painting, and is in the room of the Capitol where the House Education Committee meets.[5]