Alfred Müller or Alfred Mueller may refer to:

• Alfred Müller (entrepreneur) (1888–1945), Croatian entrepreneur
• Alfred Müller-Armack (1901–1978), German economist and politician
• Alfred Müller (runner) (1905–1959), German Olympic middle-distance runner
• Alfred Müller (general) (1915–1997), German Wehrmacht general
• Alfred Müller (swimmer) (born 1948), German Olympic swimmer
• Alfred Mueller (born 1939), American theoretical physicist
• Alfred Müller-Felsenburg, honored by the Alfred-Müller-Felsenburg-Preis literary prize in Germany
• Alfred Muller (1940-2020), former (1993-1997) French deputy

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