An acidophobe is an organism that is intolerant of acidic environments.^[1] The terms acidophobia, acidophoby and acidophobic are also used.^[2] The term acidophobe is variously applied to plants, bacteria, protozoa, animals, chemical compounds, etc. The antonymous term is acidophile.^[3]

Plants are known to be well-defined with respect to their pH tolerance, and only a small number of species thrive well under a broad range of acidity.^[4][5] Therefore the categorization acidophile/acidophobe is well-defined. Sometimes a complementary classification is used (calcicole/calcifuge, with calcicoles being "lime-loving" plants). In gardening, soil pH is a measure of acidity or alkalinity of soil, with pH = 7 indicating the neutral soil. Therefore acydophobes would prefer pH above 7. Acid intolerance of plants may be mitigated by lime addition and by calcium and nitrogen fertilizers.^[6][7]

Acidophobic species are used as a natural instrument of monitoring the degree of acidifying contamination of soil and watercourses. For example, when monitoring vegetation, a decrease of acidophobic species would be indicative of acid rain increase in the area. A similar approach is used with aquatic species.

• Whiteworms (Enchytraeus albidus), a popular live food for aquarists, are acidophobes.
• Acidophobic compounds are the ones which are unstable in acidic media.
• Acidophobic crops: alfalfa, clover^{[citation needed]}

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