De Los Santos began the 2015 season with the Harrisburg Senators of the Double–AEastern League. The Nationals promoted De Los Santos to the major leagues on July 20.[4][5] He made his major league debut the next day.[6] De Los Santos appeared in two games for the Nationals, before they optioned him to Harrisburg on July 25.[7]
On October 28, 2016, De Los Santos was claimed off waivers by the Los Angeles Angels.[10] De Los Santos was designated for assignment by the Angels on November 18, and sent outright to Triple-A on November 23.[11] He split the 2017 season between three Angels affiliates, the rookie-level AZL Angels, the Double-A Mobile BayBears, and the Triple-A Salt Lake Bees, accumulating a 2.95 ERA with 44 strikeouts in 28 total appearances. He elected free agency on November 6, 2017.[12]
Tecolotes de los Dos Laredos
On August 13, 2018, De Los Santos signed with the Tecolotes de los Dos Laredos of the Mexican League. De Los Santos struggled to a 7.59 ERA in 10 games for Dos Laredos. He became a free agent following the season.
Brantford Red Sox
On April 3, 2019, De Los Santos signed with the Brantford Red Sox of the Intercounty Baseball League.[13] De Los Santos worked to a 5.15 ERA with 42 strikeouts in 50.2 innings of work across 10 games (8 of them starts).[14] He became a free agent after the year.
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