AZIN2
Protein-coding gene in the species Homo sapiens
Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene .[ 5] [ 6] [ 7] [ 5] Antizyme inhibitor 2 does not act as arginine decarboxylase (ADC) in mammalian cells [ 8] [ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000142920 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028789 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Pitkänen LT, Heiskala M, Andersson LC (October 2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochemical and Biophysical Research Communications . 287 (5): 1051– 1057. doi :10.1006/bbrc.2001.5703 . PMID 11587527 . ^ Zhu MY, Iyo A, Piletz JE, Regunathan S (January 2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine" . Biochimica et Biophysica Acta (BBA) - General Subjects . 1670 (2): 156– 164. doi :10.1016/j.bbagen.2003.11.006 . PMC 3118518 PMID 14738999 . ^ "Entrez Gene: ADC arginine decarboxylase" .^ Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF) . The Biochemical Journal . 409 (1): 187– 192. doi :10.1042/BJ20071004 . PMID 17900240 . ^ López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity" . The Journal of Biological Chemistry . 281 (41): 30896– 30906. doi :10.1074/jbc.M602840200 PMID 16916800 .
Further reading
Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins" . DNA Research . 8 (6): 319– 327. doi :10.1093/dnares/8.6.319 PMID 11853319 . Coleman CS, Hu G, Pegg AE (May 2004). "Putrescine biosynthesis in mammalian tissues" . The Biochemical Journal . 379 (Pt 3): 849– 855. doi :10.1042/BJ20040035 . PMC 1224126 PMID 14763899 . Choi KS, Suh YH, Kim WH, Lee TH, Jung MH (March 2005). "Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity". Biochemical and Biophysical Research Communications . 328 (1): 206– 212. doi :10.1016/j.bbrc.2004.11.172 . PMID 15670771 . López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity" . The Journal of Biological Chemistry . 281 (41): 30896– 30906. doi :10.1074/jbc.M602840200 PMID 16916800 . Tian H, Liu X, Zhang B, Sun Q, Sun D (June 2007). "Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth" . Acta Biochimica et Biophysica Sinica . 39 (6): 423– 430. doi :10.1111/j.1745-7270.2007.00294.x PMID 17558447 . Levin VA, Jochec JL, Shantz LM, Aldape KD (November 2007). "Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy" . International Journal of Cancer . 121 (10): 2279– 2283. doi :10.1002/ijc.22914 PMID 17582600 . Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF) . The Biochemical Journal . 409 (1): 187– 192. doi :10.1042/BJ20071004 . PMID 17900240 .
External links
