5-Cyclohexadecenone is a macrocyclic synthetic musk with the chemical formula C16H28O. It is an unsaturated analog of cyclohexadecanone. It is also similar in chemical structure to the natural musk scents civetone and muscone.[3]
5-Cyclohexadecenone has a strong musk scent[4] with floral, amber, and civet tones.[2] It is used as a substitute for natural musk in perfumes, cosmetics, and soaps.[1][5] Trade names include Ambretone,[2] Velvione,[4] and TM-II.[5]
5-Cyclohexadecenone can exist as either of two cis/trans isomers and the commercial product is typically a mixture of the two.[5] It can be synthesized in a four-step sequence from cyclododecanone.[6]
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