The unit was formed on July 15, 1940, under the command of Col. Abner Zehm. In February 1942, Major John S. Wier became the Battalion Commander.
Major Wier requested surgical trucks for the unit. The army gave him six thousand dollars, enough for six 2+1⁄2 ton trucks to be converted for medical use.
On December 11, 1942, the 48th left Fort Dix, New Jersey, for North Africa, landing at Casablanca on December 24, 1942.
The battalion landed on Omaha Beach on June 9, 1944 (D+3 at 13:00). The battalion stayed with the 2nd Armored Division throughout the advance on into Germany and then to Berlin.
After the war the unit returned to Camp Hood, Texas, for retraining before being disbanded.
The Battalion's World War II unit insignia consisted of a rod of Asclepius crossed with a dagger, on a silver bordered, red shield, above the words "Humanity Marshalled".
At a later date the 48th Medical Battalion was reformed, again as part of the 2nd Armored Division, serving until the divisions disbandment in 1991.
