The race started and finished in Huy, with the finish line on the top of the final ascent of the Mur de Huy - one of three ascents of the Mur on the route.[3][4] The race covered the same final 90km as the men's race, totalling 130.2 km.[3] There were 8 categorised climbs:
Seven-time winner of La Flèche Wallonne Féminine Anna van der Breggen retired from the sport at the end of 2021 and therefore did not defend her 2021 title.[4]
In the race itself, a large breakaway of 15 riders was caught before the bottom of the final ascent of the Mur de Huy. On the climb, Annemiek van Vleuten of Movistar Team attacked with 400m to go on the steepest section of the ascent. However, Marta Cavalli of FDJ Nouvelle-Aquitaine Futuroscope was able to stay with van Vleuten, and passed her with around 50 metres to go before the line, winning the 2022 edition. Behind van Vleuten in third place was Demi Vollering of SD Worx, 10 seconds behind.[1][2]
