2021 JSM Challenger of Champaign–Urbana
Date	15 November – 21 November
Edition	25th
Surface	Hard (Indoor)
Location	Champaign, Illinois, United States
Champions
Singles
Stefan Kozlov
Doubles
Nathaniel Lammons / Jackson Withrow
← 2019 · JSM Challenger of Champaign–Urbana · 2022 →

The 2021 JSM Challenger of Champaign–Urbana was a professional tennis tournament played on hard courts. It was the 25th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Champaign, Illinois, United States between November 15 and November 21, 2021.

Country	Player	Rank1	Seed
GER	Daniel Altmaier	105	1
USA	Mitchell Krueger	147	2
USA	J. J. Wolf	152	3
AUS	Aleksandar Vukic	172	4
TPE	Jason Jung	173	5
IND	Prajnesh Gunneswaran	180	6
SLO	Blaž Rola	185	7
USA	Stefan Kozlov	188	8

• ¹ Rankings are as of November 8, 2021.^[1]

The following players received wildcards into the singles main draw:

• Ezekiel Clark
• Vasil Kirkov
• Aleksandar Kovacevic

The following players received entry from the qualifying draw:

• Gijs Brouwer
• Arjun Kadhe
• Ben Shelton
• Keegan Smith

• Stefan Kozlov def. Aleksandar Vukic 5–7, 6–3, 6–4.

• Nathaniel Lammons / Jackson Withrow def. Treat Huey / Max Schnur 6–4, 3–6, [10–6]