Location of teams of the 2021 CAF Women's Champions League group stage. Group A Group B
The qualification phases were made up of 6 sub-confederation qualification tournaments which began with those of UNAF for North Africa and West Africa's Zone A on 24 July 2021 and concluded on 8 September 2021. Qualification ended with the participating teams reduced to the final 8 which were made up of one winning team each from the 6 CAF sub-confederations (WAFU is split into two zones), the host nation's league-winning team and, for this edition only, an additional team from the sub-confederation of the incumbent Women's Africa Cup of Nations champions.
The draw for this edition of the tournament was held at the CAF headquarters in Cairo, Egypt on 29 September 2021 at 17:00 CAT (15:00 UTC).[6] The eight confirmed teams were put into two groups of four teams. As club competition hosts, Wadi Degla was allocated to position A1.[7]
Per statistical convention in football, matches decided in extra time are counted as wins and losses, while matches decided by a penalty shoot-out are counted as draws.