Tamara Zidanšek was the two-time defending champion, having won the last edition in 2019,[1] however she was unable to defend her title as she was still competing at the 2021 French Open, reaching the semi-final of the Grand Slam.
Jasmine Paolini won the title, defeating Arantxa Rus in the final, 6–2, 7–6(7–4).