In the regular season, ten teams (eight teams from the previous season and two teams from the 2020-21 Nationalliga B) play a round-robin league, with home and away games, for a total of 18 games each. At the end of the first phase, the eight top teams advance to the playoffs. The bottom two teams are joined by the top two teams of the Nationalliga B in the relegation playoff.[2]
The winner of the playoffs is crowned Swiss Champion. The champion and the winner of the regular season qualify to the UEFA Champions League.
The top two teams of the Relegation Playoff are qualified for the 2022–23 Swiss Women's Super League, the bottom two are relegated to 2022-23 Nationalliga B.
As FC Lugano Femminile withdrew from the Axa Women's Super League and are relegated directly, only the 9th place team of the Women's Super League will play against the top two teams of the Nationalliga B.[3] The three teams will play a round-robin playoff with home and away games. The first and second ranked teams will be promoted or remain in the AWSL, while the last placed will be relegated.