The 2021–22 season is the 66th season in the existence of FC Groningen and the club's 55th (22nd consecutive) season in the top flight of Dutch football.
In addition to the domestic league, FC Groningen participated in this season's edition of the KNVB Cup.
In the KNVB Cup, FC Groningen lost 2–1 against NEC Nijmegen in round of 16 and are eliminated from the cup.
Jørgen Strand Larsen was the top scorer of the club in this season with 17 goals; 14 goals in Eredivisie and 3 goals in KNVB Cup. (His 2nd consecutive.)
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Source: Eredivisie Rules for classification: Season in progress: 1) Most points won; 2) Less points lost; 3) Goal difference; 4) Goals scored; 5) Alphabetical order; End of season: 1) Points; 2) Goal difference; 3) Goals scored; 4) Head-to-head points; 5) Head-to-head goal difference; 6) Head-to-head away goals scored; 7) Play-off if relevant for deciding champion, relegation or participating in a European league, otherwise by draw. 8) Penalty shoot-out (only after a play-off)[2]