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This article describes the knockout stage of the 2020–21 LEN Euro League Women.

The 2020–21 Euro League Women knockout phase began on 27 February with the playoffs and ended on 1 May 2021 with the final. Olympiacos won the title.

Qualified teams

The knockout phase involves the sixteen teams which qualified as winners and runners-up of each of the eight groups in the qualification round.

Group	Winners	Runners-up
A	UVSE Hunguest Hotel	Dynamo Uralochka
B	Kinef-Surgutneftegas	CN Mataró
C	Lifebrain SIS Roma	Olympiacos
D	Astrapool Sabadell	Dunaújváros

Quarterfinals

The draw for the eight-finals was held on 7 February 2021.^[1] The first legs were played on 27 February, and the second legs were played on 13 March 2021.

Overview

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Kinef-Surgutneftegas	23–24	Dynamo Uralochka	8–11	10–7 (5–6 p)
Astrapool Sabadell	19–22	Olympiacos	14–12	5–10
CN Mataró	18–21	UVSE Hunguest Hotel	9–12	9–9
Lifebrain SIS Roma	17–21	Dunaújváros	11–11	6–10

Matches

27 February 2021 (2021-02-27) 17:00 (15:00 MSK)	Report	Kinef-Surgutneftegas	8–11	Dynamo Uralochka	Kirishi Referees: Stanojević (SRB), Ðurašković (MNE)
		Score by quarters: 2–5, 1–2, 2–3, 3–1
		Markoch, Ivanova 2	Goals	Bersneva 4

12 March 2021 (2021-03-12) 19:30 (15:30 YEKT)	Report	Dynamo Uralochka	13–15	Kinef-Surgutneftegas	Zlatoust Referees: Raković (SRB), Golikov (RUS)
		Score by quarters: 1–3, 2–1, 3–2, 1–4 PSO: 6–5
		Panfilova 5	Goals	Simanovich, Ivanova

18–18 on aggregate. Dynamo Uralochka won 6–5 on penalties.

27 February 2021 (2021-02-27) 11:45	Report	Astrapool Sabadell	14–12	Olympiacos	Piscina Can Llong, Sabadell Referees: Debreceni (HUN), Bouchez (FRA)
		Score by quarters: 3–3, 3–3, 4–4, 4–2
		Forca 5	Goals	Plevritou 3

12 March 2021 (2021-03-12) 13:00 (14:00 EET)	Report	Olympiacos	10–5	Astrapool Sabadell	Papastrateio Hall, Piraeus Referees: Várkonyi (HUN), Nicolosi (ITA)
		Score by quarters: 1–1, 2–1, 3–2, 4–1
		Eleftheriadou 3	Goals	five players 1

Olympiacos won 22–19 on aggregate.

27 February 2021 (2021-02-27) 19:00	Report	CN Mataró	9–12	UVSE Hunguest Hotel	Mataró Referees: Moiralis (GRE), Haentschel (GER)
		Score by quarters: 2–2, 1–2, 3–3, 3–5
		three players 2	Goals	Keszthelyi 3

12 March 2021 (2021-03-12) 19:30	Report	UVSE Hunguest Hotel	9–9	CN Mataró	Budapest Referees: Wengenroth (GER), Markopoulou (GRE)
		Score by quarters: 3–3, 1–0, 2–1, 3–5
		Antal 4	Goals	Lloret 3

UVSE Hunguest Hotel won 21–18 on aggregate.

27 February 2021 (2021-02-27) 18:30	Report	Lifebrain SIS Roma	11–11	Dunaújváros	Rome Referees: Castrilli (SUI), Jaumandreu (ESP)
		Score by quarters: 4–3, 2–3, 4–3, 1–2
		four players 2	Goals	Szilágyi 6

12 March 2021 (2021-03-12) 17:30	Report	Dunaújváros	10–6	Lifebrain SIS Roma	Budapest Referees: Štampalija (CRO), Oretga (ESP)
		Score by quarters: 3–1, 2–2, 3–0, 2–3
		Garda 3	Goals	Galardi, Giustini 2

Dunaújváros won 21–17 on aggregate.

Final four

The draw took place on 23 March 2021.^[2] The final four will held at the Danube Arena in Budapest, Hungary on 30 April and 1 May 2021.

Bracket

Semifinals		Final

30 April

Olympiacos	9
		1 May
UVSE Hunguest Hotel	8
		Olympiacos	7
30 April
		Dunaújváros	6
Dunaújváros	15

Dynamo Uralochka	14
		Third place

		1 May

		UVSE Hunguest Hotel	15

		Dynamo Uralochka	10