The 2020–21 season was the 75th season in existence of Unione Calcio Sampdoria and the club's ninth consecutive season in the top flight of Italian football. In addition to the domestic league, Sampdoria participated in this season's edition of the Coppa Italia. The season covered the period from 3 August 2020 to 30 June 2021.
Source: Serie A, Soccerway Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Goal difference; 5) Goals scored; 6) Draw. (Note: Head-to-head record is used only after all the matches between the teams in question have been played)[2] Notes:
^Since the winners of the 2020–21 Coppa Italia, Juventus, qualified for the Champions League, the Europa League berth awarded to the Coppa Italia winners was passed to the sixth-placed team, and the Europa Conference League berth awarded to the sixth-placed team was passed to the seventh-placed team.