The 2020–21 Professional Football League was the third highest division in Russian football. The Professional Football League is geographically divided into 4 groups.
The winners of each zone are automatically promoted into the National Football League. The bottom finishers of each zone lose professional status and are relegated into the Amateur Football League.
Source: [1] Rules for classification: 1. points won; 2. games won; 3. points in head-to-head matches; 4. games won in head-to-head matches; 5. goal difference in head-to-head matches; 6. goals scored in head-to-head matches; 7. away goals in head-to-head matches; 8. total goal difference; 9. total goals scored; 10. total away goals scored. (P) Promoted Notes:
^Team folded after season as the club decided not to apply for the PFL license for the 2021–22 season.
^Team folded after season as the club failed to receive a PFL license for the 2021–22 season.
Source: [3] Rules for classification: 1. points won; 2. games won; 3. points in head-to-head matches; 4. games won in head-to-head matches; 5. goal difference in head-to-head matches; 6. goals scored in head-to-head matches; 7. away goals in head-to-head matches; 8. total goal difference; 9. total goals scored; 10. total away goals scored. (P) Promoted; (R) Relegated
Source: [4] Rules for classification: 1. points won; 2. games won; 3. points in head-to-head matches; 4. games won in head-to-head matches; 5. goal difference in head-to-head matches; 6. goals scored in head-to-head matches; 7. away goals in head-to-head matches; 8. total goal difference; 9. total goals scored; 10. total away goals scored. (P) Promoted; (R) Relegated
Source: [5] Rules for classification: 1. points won; 2. games won; 3. points in head-to-head matches; 4. games won in head-to-head matches; 5. goal difference in head-to-head matches; 6. goals scored in head-to-head matches; 7. away goals in head-to-head matches; 8. total goal difference; 9. total goals scored; 10. total away goals scored. (P) Promoted; (R) Relegated