The 2020–21 season was the 34th season in the history of the Misr Lel Makkasa SC, and the club's 11th consecutive season in the Egyptian Premier League. In addition to the domestic league, the team participated in the Egypt Cup.
Squad
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Source: Soccerway Rules for classification: 1) Points; 2) Head-to-Head points; 3) Head-to-Head goal difference; 4) Head-to-Head goals scored; 5) Head-to-Head away goals scored; 6) Goal difference; 7) Goals scored. (Note: Head-to-head record is used only after all the matches between the teams in question have been played). Notes: