Doubles
2018 Knoxville Challenger
Final
Champions	Toshihide Matsui Frederik Nielsen
Runners-up	Hunter Reese Tennys Sandgren
Score	7–6(8–6), 7–5
Events
Singles Doubles
← 2017 · Knoxville Challenger · 2019 →

Leander Paes and Purav Raja were the defending champions but only Paes chose to defend his title, partnering Miguel Ángel Reyes-Varela. Paes lost in the quarterfinals to Alex Lawson and Jackson Withrow.

Toshihide Matsui and Frederik Nielsen won the title after defeating Hunter Reese and Tennys Sandgren 7–6^(8–6), 7–5 in the final.

	First round							Quarterfinals							Semifinals							Final
	1	L Paes MÁ Reyes-Varela	6	6
		H Hach Verdugo R Roelofse	4	2				1	L Paes MÁ Reyes-Varela	3	4
		A Lawson J Withrow	6	6					A Lawson J Withrow	6	6
	WC	JC Aragone B Fratangelo	4	4												A Lawson J Withrow	7	1	[3]
	4	M Granollers M Vervoort	4	64												T Matsui F Nielsen	5	6	[10]
		T Matsui F Nielsen	6	77					T Matsui F Nielsen	6	3	[10]
	WC	C Eubanks M Krueger	60	4				WC	T Stodder P Touliatos	2	6	[5]
	WC	Timo Stodder Preston Touliatos	77	6																			T Matsui F Nielsen	78	7
		P Polansky A Shamasdin	6	3	[10]																		H Reese T Sandgren	66	5
	Q	H Heliövaara H Laaksonen	4	6	[2]				P Polansky A Shamasdin	64	77	[10]
		R Gonzales N Lammons	3	6	[10]				R Gonzales N Lammons	77	64	[8]
	3	M Reid J-P Smith	6	3	[5]											P Polansky A Shamasdin	4	2
		H Reese T Sandgren	3	6	[10]											H Reese T Sandgren	6	6
		J Jung S Verbeek	6	3	[8]				H Reese T Sandgren	6	6
		R Galloway N Pasha	6	3	[10]				R Galloway N Pasha	2	4
	2	M Arévalo R Maytín	4	6	[3]

• Main Draw
• Qualifying Draw