This was the second overall meeting between these two teams. The last time these two teams met was in 1983, a game Florida won by a score of 24–17. The teams would meet again on September 12, 2015 at Florida's Ben Hill Griffin Stadium, a game Florida won 31-24.
After finishing their regular season with an 8–4 record, the Pirates accepted their invitation to play in the game.[5]
This was East Carolina's second Birmingham Bowl. They previously played in the 2006 PapaJohns.com Bowl (the inaugural version of that game), losing to the South Florida Bulls by a score of 24–7.
After finishing their regular season with a 6–5 record, the Gators accepted their invitation to play in the game.[6]
Florida was led by interim head coach D. J. Durkin. Durkin was the Gators defensive coordinator until former head coach Will Muschamp was released at the conclusion of the 2014 regular season. Muschamp's replacement is former Colorado State head coach Jim McElwain.
There was a Birmingham Bowl in January and December of 2015, and none in 2009 or 2019. The game in January 2021 was cancelled due to the COVID-19 pandemic.