The 2015–16 Copa Argentina was the seventh edition of the Copa Argentina, and the fifth since the relaunch of the tournament in 2011. The competition began on January 29, 2016. Defending champions Boca Juniors were eliminated by Rosario Central in the quarterfinals. By winning the competition, River Plate won the right to play in the 2017 Copa Libertadores and the 2016 Supercopa Argentina.
The two teams promoted, the losing team of the seventh stage, two losing teams of the sixth stage, four losing teams of the fifth stage, and the best losing team of the fourth stage of the 2015 tournament qualified.
In this first round, 7 teams from the Torneo Federal A and 9 teams from the Torneo Federal B participated. The round was played between January 31 and February 20, on a home-and-away two-legged tie. The 8 winning teams advanced to the Final Round.
Stadium: La Visera de Cemento Referee: Esteban Nasier
Sansiena won 2–1 on aggregate.
Group B
In this round, 3 teams from the Torneo Federal A and 3 teams from the Torneo Federal B participated. The round was played between January 29 and February 17, on a home-and-away two-legged tie. The 3 winning teams advanced to the Final Round.
This round will have 11 qualified teams from the Regional Round, 11 qualified teams from the Metropolitan Zone (5 teams from Primera B Metro; 4 teams from Primera C and 2 teams from Primera D), 12 teams from Primera B Nacional and 30 teams from Primera División. The round was played between May 4 and July 31, in a single knock-out match format. The 32 winning teams advanced to the Round of 32. The draw took place on April 7, 2016.
This round will have the 32 qualified teams from the Round of 64. The round was played between August 2 and August 31, in a single knock-out match format. The 16 winning teams advanced to the Round of 16.
Stadium: Estadio Antonio Romero Referee: Silvio Trucco
Round of 16
This round will have the 16 qualified teams from the Round of 32. The round was played between September 3 and October 19, in a single knock-out match format. The 8 winning teams advanced to the Quarterfinals.
This round will have the 8 qualified teams from the Round of 16. The round was played between October 5 and November 17, in a single knock-out match format. The 4 winning teams advanced to the Semifinals.
This round will have the 4 qualified teams from the Quarterfinals. The round was played between November 30 and December 1, in a single knock-out match format. The 2 winning teams advanced to the Final.