The 2010–11 Cayman Islands Premier League season was the 32nd edition of top tier Cayman Islands Premier Leaguefootball competition in the Cayman Islands. It began on 10 October 2010 and ended on 30 April 2011.
Sunset FC were relegated to the Cayman Islands First Division after finishing eighth place in last season's competition. Taking their place in the competition were the champions of the First Division, East End United.