The 2010 season was the 23rd in the history of the Newcastle Knights. Coached by Rick Stone and captained by Kurt Gidley, they competed in the National Rugby League's 2010 Telstra Premiership, finishing the regular season 11th (out of 16), failing to reach the finals.

Newcastle's captain, Kurt Gidley was also selected to captain New South Wales throughout the mid-season 2010 State of Origin series.

2010 NRL season v t e
Pos.	Team	Pld	W	D	L	B	PF	PA	PD	Pts
1	St. George Illawarra Dragons (P)	24	17	0	7	2	518	299	+219	38
2	Penrith Panthers	24	15	0	9	2	645	489	+156	34
3	Wests Tigers	24	15	0	9	2	537	503	+34	34
4	Gold Coast Titans	24	15	0	9	2	520	498	+22	34
5	New Zealand Warriors	24	14	0	10	2	539	486	+53	32
6	Sydney Roosters	24	14	0	10	2	559	510	+49	32
7	Canberra Raiders	24	13	0	11	2	499	493	+6	30
8	Manly Warringah Sea Eagles	24	12	0	12	2	545	510	+35	28
9	South Sydney Rabbitohs	24	11	0	13	2	584	567	+17	26
10	Brisbane Broncos	24	11	0	13	2	508	535	−27	26
11	Newcastle Knights	24	10	0	14	2	499	569	−70	24
12	Parramatta Eels	24	10	0	14	2	413	491	−78	24
13	Canterbury-Bankstown Bulldogs	24	9	0	15	2	494	539	−45	22
14	Cronulla-Sutherland Sharks	24	7	0	17	2	354	609	−255	18
15	North Queensland Cowboys	24	5	0	19	2	425	667	−242	14
16	Melbourne Storm	24	14	0	10	2	489	363	+126	01

¹ Melbourne were deducted eight premiership points and barred from receiving premiership points for the rest of the season due to gross long-term salary cap breaches.^[1]