The 2010–11 Toto Cup Leumit was the twenty-nine season of the third most important football tournament in Israel since its introduction and seventh under the current format. It held in two stages. First, sixteen Liga Leumit teams were divided into four groups. The winners and runners-up advanced to the Quarterfinals. Quarterfinals, Semifinals and Finals were held as one-legged matches, with the Final played at the Ramat Gan Stadium.
The defending champions were Ironi Kiryat Shmona, making it their second Toto Cup title overall, due to the promotion in the last season the club could not defend their title.