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The 2001 UNCAF Interclub Cup served as qualification to the 2002 CONCACAF Champions' Cup; it also defined C.S.D. Municipal as the Central American champion of the season. The final round was played at San José, Costa Rica.

First round

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification
1	Saprissa	3	2	1	0	5	3	+2	7	Qualification for Final round
2	Comunicaciones	3	1	1	1	3	3	0	4	Qualification for Final round
3	Tauro	3	1	1	1	3	3	0	4
4	Motagua	3	0	1	2	1	3	−2	1

Source: ^{[citation needed]}

Comunicaciones qualifies for the Final Round ahead of Tauro F.C. based on head-to-head results.

15 August 2001 Day 1	Saprissa	1–1	Tauro	Guatemala City, Guatemala
	Saborío 56'		6' Nazarit	Stadium: Estadio Doroteo Guamuch Flores

15 August 2001 Day 1	Comunicaciones	0–0	Motagua	Guatemala City, Guatemala
				Stadium: Estadio Doroteo Guamuch Flores

17 August 2001 Day 2	Motagua	0–1	Tauro	Guatemala City, Guatemala
			6' Wiltshire	Stadium: Estadio Doroteo Guamuch Flores

17 August 2001 Day 2	Comunicaciones	1–2	Saprissa	Guatemala City, Guatemala
	Valencia 17'		10' Cordero 82' Saborío	Stadium: Estadio Doroteo Guamuch Flores

19 August 2001 Day 3	Comunicaciones	2–1	Tauro	Guatemala City, Guatemala
	Valencia 36' Rivera 59'		12' Rodríguez	Stadium: Estadio Doroteo Guamuch Flores

19 August 2001 Day 3	Motagua	1–2	Saprissa	Guatemala City, Guatemala
	Leyes 16' (pen.)		2' Núñez 69' Centeno	Stadium: Estadio Doroteo Guamuch Flores

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification
1	Municipal	3	1	2	0	9	2	+7	5	Qualification for Final round
2	Olimpia	3	1	2	0	6	0	+6	5	Qualification for Final round
3	Alajuelense	3	1	2	0	8	3	+5	5
4	Plaza Amador	3	0	0	3	1	19	−18	0

Source: ^{[citation needed]}

8 August 2001 Day 1	Alajuelense	6–1	Plaza Amador	Tegucigalpa, Honduras
	Miso 25' Oviedo 39' Delgado 43' (pen.) Castro 59' Rosella 60' Solís 66'		79' Román	Stadium: Estadio Tiburcio Carías Andino

8 August 2001 Day 1	Olimpia	0–0	Municipal	Tegucigalpa, Honduras
				Stadium: Estadio Tiburcio Carías Andino

10 August 2001 Day 2	Municipal	7–0	Plaza Amador	Tegucigalpa, Honduras
	Plata 21' 28' 83' Barros 34' 88' Estrada 71' Romero 90'			Stadium: Estadio Tiburcio Carías Andino

10 August 2001 Day 2	Olimpia	0–0	Alajuelense	Tegucigalpa, Honduras
				Stadium: Estadio Tiburcio Carías Andino

12 August 2001 Day 3	Alajuelense	2–2	Municipal	Tegucigalpa, Honduras
	Romero 16' Acevedo 32'		36' 90' Jiménez	Stadium: Estadio Tiburcio Carías Andino

12 August 2001 Day 3	Olimpia	6–0	Plaza Amador	Tegucigalpa, Honduras
	Ulloa 13' Fuentes 15' Costa 29' 80' 88' Tilguath 41'			Stadium: Estadio Tiburcio Carías Andino

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification
1	Municipal	3	2	1	0	7	2	+5	7	Qualification for 2002 CONCACAF Champions' Cup
2	Saprissa	3	2	1	0	7	4	+3	7
3	Olimpia	3	1	0	2	4	5	−1	3
4	Comunicaciones	3	0	0	3	2	9	−7	0

Source: ^{[citation needed]}

12 September 2001 Day 1	Saprissa	1–1	Municipal	San Juan de Tibás, Costa Rica
	Centeno 62'		3' Plata	Stadium: Estadio Ricardo Saprissa Aymá

12 September 2001 Day 1	Comunicaciones	0–2	Olimpia	San Juan de Tibás, Costa Rica
			70' Fuentes 72' Domínguez	Stadium: Estadio Ricardo Saprissa Aymá

14 September 2001 Day 2	Saprissa	3–1	Olimpia	San Juan de Tibás, Costa Rica
	Centeno 52' 56' Campos 81'		61' Tosello	Stadium: Estadio Ricardo Saprissa Aymá

14 September 2001 Day 2	Comunicaciones	0–4	Municipal	San Juan de Tibás, Costa Rica
			3' Girón 55' Barros 63' (pen.) Plata 83' Ruiz	Stadium: Estadio Ricardo Saprissa Aymá

16 September 2001 Day 3	Saprissa	3–2	Comunicaciones	San Juan de Tibás, Costa Rica
	Centeno 10' Ramírez 18' Núñez 75'		37' 50' Estrada	Stadium: Estadio Ricardo Saprissa Aymá

16 September 2001 Day 3	Municipal	2–1	Olimpia	San Juan de Tibás, Costa Rica
	Plata 25' Ruiz 75'		40' Costa	Stadium: Estadio Ricardo Saprissa Aymá

Municipal, Saprissa, and Olimpia qualified to the 2002 CONCACAF Champions' Cup.

2001 UNCAF champions
Municipal 3rd title