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The 2001 Soul Train Music Awards were held on February 28, 2001, at the Shrine Auditorium in Los Angeles, California. The show was hosted by Queen Latifah, Mýa, and Shemar Moore.

• The Isley Brothers

• Jay Z

• Destiny's Child

Winners are in bold text.

• Dr. Dre – Dr. Dre 2001
  • Eminem – The Marshall Mathers LP
  • Jay Z – The Dynasty: Roc La Familia
  • R. Kelly – TP-2.com

• R. Kelly – TP-2.com
  • D'Angelo – Voodoo
  • Sisqó – Unleash the Dragon
  • Carl Thomas – Emotional

• Jill Scott – Who Is Jill Scott? Words and Sounds Vol. 1
  • Toni Braxton – The Heat
  • Mýa – Fear of Flying
  • Kelly Price – Mirror Mirror

• Jagged Edge – J.E. Heartbreak
  • Mary Mary – Thankful
  • Next – Welcome II Nextasy
  • Lucy Pearl – Lucy Pearl

• R. Kelly – "I Wish"
  • Avant – "Separated"
  • D'Angelo – "Untitled (How Does It Feel)"
  • Carl Thomas – "I Wish"

• Yolanda Adams – "Open My Heart"
  • Erykah Badu – "Bag Lady"
  • Mary J. Blige – "Your Child"
  • Jill Scott – "Gettin' In the Way"

• Jagged Edge – "Let's Get Married"
  • Destiny's Child – "Independent Women, Part I"
  • Whitney Houston and Deborah Cox – "Same Script, Different Cast"
  • Lucy Pearl – "Dance Tonight"

• Mystikal – "Shake Ya Ass"
  • D'Angelo – "Untitled (How Does It Feel)"
  • Eminem – "Stan"
  • OutKast – "Ms. Jackson"

• Nelly
  • Lil' Bow Wow
  • Jill Scott
  • Carl Thomas

• Mary Mary – Thankful
  • Chester D.T. Baldwin and Music Ministry Mass – Sing It on Sunday Morning!
  • Mississippi Mass Choir – Emmanuel (God With Us)
  • Lee Williams and the Spiritual QC's – Good Time

• Destiny's Child – "Survivor"
• Jagged Edge
• Yolanda Adams
• Jay Z and The Dogg Pound – Medley: "I Just Wanna Love U (Give It 2 Me)" / "Change The Game"
• Mýa
• Mystikal
• Nivea
• Isley Brothers Tribute: Kelly Price – "Groove With You", Sisqo – "Between the Sheets", Gerald Levert – "Voyage to Atlantis" and "Tears"
• Nelly – "Ride wit Me"
• Jill Scott – "A Long Walk"
• Carl Thomas – Medley: "Emotional" / "I Wish"