The forty-third edition of the Caribbean Series (Serie del Caribe) was held from February 1 through February 6 of 2001 with the champion baseball teams of the Dominican Republic, Águilas Cibaeñas; Mexico, Naranjeros de Hermosillo; Puerto Rico, Cangrejeros de Santurce, and Venezuela, Cardenales de Lara. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Estadio General Ángel Flores in Culiacán, Mexico.

This section is empty. You can help by adding to it. (February 2014)

Country	Club	W	L	W/L %	Managers
Dominican Republic	Águilas Cibaeñas	4	2	.667	Félix Fermín
Mexico	Naranjeros de Hermosillo	3	3	.500	Derek Bryant
Venezuela	Cardenales de Lara	3	3	.500	Nick Leyva
Puerto Rico	Criollos de Caguas	2	4	.333	Sandy Alomar Sr. *

  * Had to attend family issues and was replaced by coach José López.

• Bjarkman, Peter. Diamonds around the Globe: The Encyclopedia of International Baseball. Greenwood. ISBN 978-0-313-32268-6
• Serie del Caribe : History, Records and Statistics (Spanish)
• Estadísticas Serie del Caribe 2001 (Spanish)