2-Furonitrile is a colorless derivative of furan possessing a nitrile group.
Industrial synthesis is based on the vapor phase ammoxidation of furfural with ammonia over bismuth molybdate catalyst at 440-480 °C.[3]
Numerous laboratory methods also exist; for the instance oxidative dehydration of furfural with ammonia salts using hypervalent iodine reagents[4] or n-bromosuccinimide.[5] From furfural aldoxime (with thionyl chloride-benzotriazole,[6] triphenylphosphine-iodine reagents,[7] or heating in DMSO[8]) and furoic acid amide (flash vacuum pyrolysis).[9]
2-Furonitrile currently has no major applications but it is used as an intermediate in pharmaceutical and fine chemical synthesis. It has been suggested as a potential sweetening agent, as it has about 30 times the sweetening power of sucrose.[10]
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