The 1988 Copa Libertadores de América was the 29th edition of the Copa Libertadores, South America's premier international club football tournament organized by CONMEBOL. This season's defending champion Peñarol of Uruguay entered the tournament in the third stage, where they were defeated by San Lorenzo of Argentina. In the finals, Nacional defeated Newell's Old Boys for their third title.
The champions and runners-up of each football association were drawn into the same group along with another football association's participating teams. Three clubs from Uruguay competed as Peñarol was champion of the 1987 Copa Libertadores. They entered the tournament in the third stage.
The group winners and runners-up were drawn in the second stage of the competition. The away goals rule was applied to determine the winner between Nacional and Universidad Católica.