The 1980 Tanduay Esquires season was the sixth season of the franchise in the Philippine Basketball Association (PBA).

Tanduay's seven-foot import Paul Zaretsky sprained his ankle in a workout and as a result, Tanduay lost their first game of the season to Honda, playing with only one import, Kevin Cluess. Zaretsky never got a chance to play and was sent home in favor of 6-8 Odell Ball, a former center of Marquette University. ^[1]

For the third straight season, Tanduay advances into the round of four of the league's most prestigious tournament, the All-Filipino. The Esquires posted a 5-4 and 3-2 won-loss slates in the eliminations and quarterfinal phase. In the one-round robin among the four semifinalist, the Esquires lost to unbeaten Crispa Redmanizers, 98-101, in the last playing date on December 4 as they failed to create a three-way tie and a playoff with Toyota for the second finals berth. Tanduay placed third by winning their series against Gilbey's Gin.

Tanduay Esquires roster
Players	Coaches
Pos. No. Nat. Name Ht. Wt. F 2 Monzon, Abelardo 6 ft 1 in (1.85 m) Letran G 7 Dela Rosa, Roberto 5 ft 11 in (1.80 m) Far Eastern F 10 Sanchez, Victor 6 ft 3 in (1.91 m) Mapúa G/F 11 Manansala, Jaime 5 ft 11 in (1.80 m) UE F 13 Gutierrez, Alberto 6 ft 2 in (1.88 m) Ateneo de Davao F/C 15 Capacio, Ely 6 ft 4 in (1.93 m) F 16 Cleofas, Ricardo 5 ft 11 in (1.80 m) Ateneo G 18 Canent, Rene 5 ft 8 in (1.73 m) José Rizal C 23 Evangelista, Rolando 6 ft 3 in (1.91 m) San Beda F/C 24 Castillo, Nathaniel 6 ft 2 in (1.88 m) Letran G 25 Pineda, Rolando 5 ft 9 in (1.75 m) UE F 35 Cluess, Kevin (I) 6 ft 4 in (1.93 m) St.John's University G 40 Bilbao, Miguel 5 ft 8 in (1.73 m) De La Salle F/C 41 Ball, Odell (I) 6 ft 8 in (2.03 m) Marquette	Head coach Valentin Eduque Assistant coach(es) Legend (C) Team captain (I) Import Injured