The 1980 Chattanooga Moccasins football team represented the University of Tennessee at Chattanooga as a member of the Southern Conference (SoCon) in the 1980 NCAA Division I-A football season. The Moccasins were led by first-year head coach Bill Oliver and played their home games at Chamberlain Field. They finished the season 8–3 overall and 5–2 in SoCon play to place second.^[1]

Date	Opponent	Site	Result	Attendance	Source
September 6	at Jacksonville State*	Paul Snow Stadium Jacksonville, AL	W 16–13	12,000	[2]
September 13	at Middle Tennessee*	Johnny "Red" Floyd Stadium Murfreesboro, TN	W 32–7	10,000	[3]
September 20	Appalachian State	Chamberlain Field Chattanooga, TN	W 14–7	11,000	[4]
September 27	at The Citadel	Johnson Hagood Stadium Charleston, SC	L 13–29	18,345	[5]
October 4	Furman	Chamberlain Field Chattanooga, TN	L 28–42	11,000	[6]
October 11	at VMI	Alumni Memorial Field Lexington, VA	W 55–10		[7]
October 18	at Marshall	Fairfield Stadium Huntington, WV	W 21–11		[8]
October 25	East Tennessee State	Chamberlain Field Chattanooga, TN	W 26–14	10,000	[9]
November 8	Western Carolina	Chamberlain Field Chattanooga, TN	W 39–14	9,000	[10]
November 15	Illinois State*	Chamberlain Field Chattanooga, TN	W 27–17	5,200	[11]
November 22	at Vanderbilt*	Dudley Field Nashville, TN	L 29–31	22,700	[12]
*Non-conference game Homecoming

^[13]