The 1972 North Carolina Central Eagles football team represented North Carolina Central University as a member of the Mid-Eastern Athletic Conference (MEAC) during the 1972 NCAA College Division football season. Led by fifth-year head coach George Quiett, the Eagles compiled an overall record of 9–2, with a mark of 5–1 in conference play, and finished as MEAC champion.

Date	Opponent	Site	Result	Attendance	Source
September 9	Winston-Salem State*	Durham County Memorial Stadium Durham, NC	W 29–6	12,000	[1]
September 16	at Elon*	Burlington Memorial Stadium Burlington, NC	W 41–21	6,000	[2]
September 23	Livingstone*	Durham County Memorial Stadium Durham, NC	W 47–13	10,000	[3]
September 30	at Morgan State	Hughes Stadium Baltimore, MD	W 29–7	5,117–7,000	[4][5]
October 14	at Delaware State	Alumni Stadium Dover, DE	L 10–14	10,000	[6]
October 21	Maryland Eastern Shore	Durham County Memorial Stadium Durham, NC	W 42–20	16,000	[7]
October 28	at South Carolina State	State College Stadium Orangeburg, SC	W 43–0	7,429–9,000	[8][9]
November 4	Johnson C. Smith*	Durham County Memorial Stadium Durham, NC	W 29–8	8,000	[10]
November 11	at Howard	Howard Stadium Washington, DC	W 14–13	8,000–9,800	[11][12]
November 18	vs. North Carolina A&T	Wallace Wade Stadium Durham, NC (rivalry)	W 9–7	20,000–33,000	[13][14]
December 2	vs. No. 8 Grambling*	Wallace Wade Stadium Durham, NC (Pelican Bowl)	L 6–56	22,500	[15]
*Non-conference game Homecoming Rankings from AP Poll released prior to the game

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