The 1968 Purdue Boilermakers football team represented Purdue University during the 1968 Big Ten Conference football season. Led by 13th-year head coach Jack Mollenkopf, the Boilermakers compiled an overall record of 8–2 with a mark of 5–2 in conference play, tying for third place in the Big Ten. Purdue played home games at Ross–Ade Stadium in West Lafayette, Indiana.

Date	Opponent	Rank	Site	TV	Result	Attendance	Source
September 21	Virginia*	No. 1	Ross–Ade Stadium West Lafayette, IN		W 44–6	60,384	[1]
September 28	at No. 2 Notre Dame*	No. 1	Notre Dame Stadium Notre Dame, IN (rivalry)	ABC	W 37–22	59,075
October 5	at Northwestern	No. 1	Dyche Stadium Evanston, IL		W 43–6	45,163
October 12	at No. 4 Ohio State	No. 1	Ohio Stadium Columbus, OH		L 0–13	84,834
October 19	Wake Forest*	No. 5	Ross–Ade Stadium West Lafayette, IN		W 28–27	57,694	[2]
October 26	Iowa	No. 7	Ross–Ade Stadium West Lafayette, IN		W 44–14	61,927
November 2	Illinois	No. 6	Ross–Ade Stadium West Lafayette, IN (rivalry)		W 35–17	62,321
November 9	at Minnesota	No. 6	Memorial Stadium Minneapolis, MN	ABC	L 13–27	49,780
November 16	at Michigan State	No. 15	Spartan Stadium East Lansing, MI		W 9–0	68,362
November 23	Indiana	No. 12	Ross–Ade Stadium West Lafayette, IN (Old Oaken Bucket)		W 38–35	63,294
*Non-conference game Homecoming Rankings from AP Poll released prior to the game

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• Leroy Keyes 25 rushes, 214 yards

• Leroy Keyes 28 rushes, 140 yards