The 1960–61 Yugoslav Second League season was the 15th season of the Second Federal League (Serbo-Croatian: Druga savezna liga), the second level association football competition of SFR Yugoslavia, since its establishment in 1946. The league was contested in two regional groups (West Division and East Division), with 12 clubs each.

A total of twelve teams contested the league, including nine sides from the 1959–60 season, one club relegated from the 1959–60 Yugoslav First League and two sides promoted from the third tier leagues played in the 1959–60 season. The league was contested in a double round robin format, with each club playing every other club twice, for a total of 22 rounds. Two points were awarded for wins and one point for draws.

Sloboda were relegated from the 1959–60 Yugoslav First League after finishing in the 12th place of the league table. The two clubs promoted to the second level were Čelik and Karlovac.

Banja
Luka

Karlovac

Ljubljana

Osijek

Sarajevo

Šibenik

Tuzla

Varaždin

Zagreb

Zenica

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Locations of teams' home cities in the 1960–61 Yugoslav Second League West

Team	Location	Federal subject	Position in 1959–60
Borac Banja Luka	Banja Luka	SR Bosnia and Herzegovina	0033rd
Čelik	Zenica	SR Bosnia and Herzegovina	—
Karlovac	Karlovac	SR Croatia	—
Lokomotiva	Zagreb	SR Croatia	0088th
Proleter Osijek	Osijek	SR Croatia	0066th
Sloboda	Tuzla	SR Bosnia and Herzegovina	—
Šibenik	Šibenik	SR Croatia	0055th
Trešnjevka	Zagreb	SR Croatia	0022nd
Odred / Triglav Ljubljana1	Ljubljana	SR Slovenia	01010th
Varteks	Varaždin	SR Croatia	0077th
NK Zagreb	Zagreb	SR Croatia	0099th
Željezničar Sarajevo	Sarajevo	SR Bosnia and Herzegovina	0044th

^{1 Odred renamed to Triglav on 22 December 1960.}

A total of twelve teams contested the league, including nine sides from the 1959–60 season, one club relegated from the 1959–60 Yugoslav First League and two sides promoted from the third tier leagues played in the 1959–60 season. The league was contested in a double round robin format, with each club playing every other club twice, for a total of 22 rounds. Two points were awarded for wins and one point for draws.

Budućnost were relegated from the 1959–60 Yugoslav First League after finishing in the 11th place of the league table. The two clubs promoted to the second level were Bačka and Rudar.

Bačka

K. Mitrovica

Kragujevac

Nikšić

Niš

Novi Sad

Prilep

Sombor

S. Mitrovica

Subotica

Šabac

Titograd

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Locations of teams' home cities in the 1960–61 Yugoslav Second League East

Team	Location	Federal subject	Position in 1959–60
Bačka	Bačka Palanka	SAP Vojvodina	—
Budućnost	Titograd	SR Montenegro	—
Mačva Šabac	Šabac	SR Serbia	0066th
Novi Sad	Novi Sad	SAP Vojvodina	0022nd
Pobeda	Prilep	SR Macedonia	0044th
Radnički Kragujevac	Kragujevac	SR Serbia	01010th
Radnički Niš	Niš	SR Serbia	0099th
Radnički Sombor	Sombor	SAP Vojvodina	0077th
Rudar	Kosovska Mitrovica	SAP Kosovo	—
Spartak Subotica	Subotica	SAP Vojvodina	0055th
Srem	Sremska Mitrovica	SAP Vojvodina	0088th
Sutjeska	Nikšić	SR Montenegro	0033rd

• 1960–61 Yugoslav First League
• 1960–61 Yugoslav Cup