The 1959 Hardin–Simmons Cowboys football team was an American football team that represented Hardin–Simmons University in the Border Conference during the 1959 college football season. In its fifth and final season under head coach Sammy Baugh, the team compiled a 3–7 record (2–2 against conference opponents), tied for third place in the conference, and was outscored by a total of 244 to 154.^[1][2][3] The team played its three home games at Public Schools Stadium in Abilene, Texas.^[4][5][6]

No Hardin-Simmons players were named to the 1959 All-Border Conference football team.^[7]

Date	Opponent	Site	Result	Attendance	Source
September 17	North Texas State*	Public Schools Stadium Abilene, TX	L 24–40	11,000	[4]
September 26	at Wichita*	Veterans Field Wichita, KS	L 13–27
October 3	at Auburn*	Cliff Hare Stadium Auburn, AL	L 12–35	23,000	[8]
October 10	at Georgia*	Sanford Stadium Athens, GA	L 6–35	25,000	[9]
October 17	at Tulsa*	Skelly Field Tulsa, OK	L 8–16	12,317
October 24	at West Texas State	Kimbrough Memorial Stadium Canyon, TX	W 22–0
October 31	Texas Western	Public Schools Stadium Abilene, TX	W 25–14
November 7	Trinity (TX)*	Public Schools Stadium Abilene, TX	W 23–15
November 14	at New Mexico A&M	Memorial Stadium Las Cruces, NM	L 13–42
November 21	at Arizona State	Sun Devil Stadium Tempe, AZ	L 8–14
*Non-conference game Homecoming