The 1945 West Texas State Buffaloes football team represented West Texas State College—now known as West Texas A&M University–as a member of the Border Conference during the 1946 college football season. Led by third-year head coach Gus Miller, the Buffaloes compiled an overall record of 2–6 with a mark of 0–2 in conference play, placing third in the Border Conference.

Date	Time	Opponent	Site	Result	Attendance	Source
September 15	8:30 p.m.	Eastern New Mexico*	Buffalo Stadium Canyon, TX	W 56–7		[1][2]
September 22		at Baylor*	Municipal Stadium Waco, TX	L 0–32	6,000	[3]
September 29	8:00 p.m.	at Tulsa*	Skelly Field Tulsa, OK	L 0–32	3,500	[4][5]
October 6	7:30 p.m.	New Mexico	Buffalo Stadium Canyon, TX	L 0–13		[6][7]
October 13	8:00 p.m.	at Amarillo AAF*	Butler Field Amarillo, TX	L 12–21		[8][9]
October 27		at Texas Tech	Tech Field Lubbock, TX	L 6–12	6,000	[10]
November 3	3:00 p.m.	Dalhart AAF*	Buffalo Stadium Canyon, TX	W 21–0	4,000	[11][12][13]
November 17		at Colorado College*	Washburn Field Colorado Springs, Co	L 19–20	5,000	[14]
*Non-conference game Homecoming All times are in Central time

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