The 1942 All-Big Six Conference football team consists of American football players chosen by various organizations for All-Big Six Conference teams for the 1942 college football season. The selectors for the 1942 season included the Associated Press (AP) and the United Press (UP).

• Huell Hamm, Oklahoma (AP-1 [QB]; UP-1)
• Ray Evans, Kansas (AP-1 [HB]; UP-1)
• Bob Steuber, Missouri (AP-1 [HB]; UP-1)
• Paul Darling, Iowa State (AP-1 [FB]; UP-2)
• Royal Lohry, Iowa State (AP-2 [HB]; UP-1)
• Harold Adams, Missouri (AP-2 [QB]; UP-2)
• Bill Campbell, Oklahoma (AP-2 [HB])
• Don Reece, Missouri (AP-2 [FB])
• Kerwin Eisenhart, Nebraska (UP-2)
• Thomas Davis, Oklahoma (UP-2)

• Bert Ekern, Missouri (AP-1; UP-1)
• Walt Lamb, Oklahoma (AP-1; UP-1)
• Marshall Shurnas, Missouri (AP-2; UP-2)
• James Tyree, Oklahoma (AP-2)
• Marvin Thompson, Nebraska (UP-2)

• Vic Schleigh, Nebraska (AP-1; UP-1)
• Homer Simmons, Oklahoma (AP-1)
• Edward Hodges, Missouri (AP-2; UP-1)
• Bernard Pepper, Missouri (AP-2; UP-2)
• LaVerne McGraw, Iowa State (UP-2)

• Mike Fitzgerald, Missouri (AP-1; UP-1)
• Clare Morford, Oklahoma (AP-1; UP-1)
• Verlie Abrams, Missouri (AP-2)
• Charles Duda, Nebraska (AP-2; UP-2)
• Neill, Kansas State (UP-2)

• Jack Marsee, Oklahoma (AP-1; UP-2)
• Jeff Davis, Missouri (AP-2; UP-1)

• 1942 College Football All-America Team