The 1942–43 Copa México Copa México, was the 27th staging of this Mexican football cup competition.

The competition started on May 30, 1943, and concluded on September 19, 1943, with the final, held at the Parque Asturias in México DF, in which Moctezuma lifted the trophy for first time.

In April 1943 in an initiative of América and Atlante started the professional era in Mexican soccer, Necaxa didn't accept that resolution and decided to retire as well the Selección Jalisco which was dissolved.

The clubs Guadalajara and Atlas as well Orizaba and Veracruz joined the league, so, the Cup Tournament of 1942–43 season was the first one in the Professional Era.

Group A

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification
1	Club España (Mexico City)	4	3	0	1	16	6	+10	6	Advanced to the next phase
2	Atlante F.C. (Mexico City)	4	2	1	1	11	6	+5	5
3	Orizaba (Orizaba)	4	2	0	2	6	9	−3	4
4	Moctezuma (Orizaba)	4	1	1	2	10	13	−3	3
5	Veracruz (Veracruz)	4	1	0	3	8	17	−9	2

Results

Group B

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification
1	Marte (Mexico City)	4	3	0	1	10	5	+5	6	Advanced to the next phase
2	Asturias (Mexico City)	4	2	0	2	8	4	+4	4
3	Guadalajara (Guadalajara)	4	2	0	2	7	9	−2	4
4	América (Mexico DF)	4	2	0	2	6	8	−2	4
5	Atlas (Guadalajara)	4	1	0	3	6	11	−5	2

Results

	Quarterfinals From August 8 to August 29					Semifinals September 5 and September 12					Final September 19
	América		2
	Orizaba		3
						Orizaba		1
						Moctezuma		3
	Marte		0
	Moctezuma		2
											Moctezuma		5
											Atlante F.C.		3
	Atlante F.C.		6
	Guadalajara		1
						Atlante F.C.		2
						Asturias		1
	Asturias		4
	Club España		3

Moctezuma Won the cup

• Mexico - Statistics of Copa México in season 1942/1943. (RSSSF)