Α-Καδινόλη

Η χημική δομή της α-καδινόλης

Η α-καδινόλη ή αλλιώς 10α-υδροξυ-4-καδινένιο είναι οργανική ένωση που χημικά χαρακτηρίζεται ως σεσκιτερπενοειδής αλκοόλη.[1][2] Αποτελείται από δεκαπέντε άτομα C και φέρει μία υδροξυλική ομάδα.

Εξάπλωση

Απαντάται με φυσικό τρόπο συνήθως σε αιθέρια έλαια και εκχυλίσματα πολλών φυτών, όπως π.χ.

Βιολογική δραστηριότητα

Η α-καδινόλη θεωρείται ότι δρα ως αντιμυκητιακή[12] και ηπατοπροστατευτική[14] ουσία, ενώ έχει προταθεί ως πιθανή θεραπεία για την -ανθεκτική στα φάρμακα- φυματίωση.[5]

Παραπομπές

  1. ↑ Borg-Karlson, A (1981). «Configurations and conformations of torreyol (δ-cadinol), α-cadinol, T-muurolol and T-cadinol». Tetrahedron 37 (22): 425–430. doi:10.1016/S0040-4020(01)92031-9. 
  2. ↑ V. Herout; V. Sýkora (1958). «The chemistry of cadinenes and cadinols». Tetrahedron 4 (3–4): 246–255. doi:10.1016/0040-4020(58)80046-0. 
  3. ↑ Boligon, AA; Schwanz, TG; Piana, M; Bandeira, RV; Frohlich, JK; Brum, TF; Zadra, M; Athayde, ML (2012). «Chemical composition and antioxidant activity of the essential oil of Tabernaemontana catharinensis A. DC. Leaves». Natural Product Research 27: 1. doi:10.1080/14786419.2011.653971. PMID 22273350. 
  4. ↑ Ho, CL; Liao, PC; Wang, EI; Su, YC (2011). «Composition and antimicrobial activity of the leaf and twig oils of Litsea acutivena from Taiwan». Natural Product Communications 6 (11): 1755–8. doi:10.1177/1934578X1100601145. PMID 22224304. 
  5. ↑ 5,0 5,1 Bueno, J; Escobar, P; Martínez, JR; Leal, SM; Stashenko, EE (2011). «Composition of three essential oils, and their mammalian cell toxicity and antimycobacterial activity against drug resistant-tuberculosis and nontuberculous mycobacteria strains». Natural Product Communications 6 (11): 1743–8. PMID 22224302. 
  6. ↑ De Freitas, JG; Da Camara, CA; De Moraes, MM; Da Silva, HC (2011). «Volatile constituents of two species of Protium from the Atlantic rainforest in the state of Pernambuco, Brazil». Natural Product Communications 6 (11): 1727–30. PMID 22224298. 
  7. ↑ Muriel, KA; Félix, TZ; Figueredo, G; Chalard, P; n'Guessan, YT (2011). «Essential oil of three Uvaria species from Ivory Coast». Natural Product Communications 6 (11): 1715–8. PMID 22224295. 
  8. ↑ Lago, JH; Souza, ED; Mariane, B; Pascon, R; Vallim, MA; Martins, RC; Baroli, AA; Carvalho, BA και άλλοι. (2011). «Chemical and biological evaluation of essential oils from two species of Myrtaceae - Eugenia uniflora L. And Plinia trunciflora (O. Berg) Kausel». Molecules (Basel, Switzerland) 16 (12): 9827–37. doi:10.3390/molecules16129827. PMID 22117172. 
  9. ↑ Firozy, M; Talebpour, Z; Sonboli, A (2011). «Essential oil composition and antioxidant activities of the various extracts of Tanacetum sonbolii Mozaff. (Asteraceae) from Iran». Natural Product Research 26: 1. doi:10.1080/14786419.2011.636746. PMID 22115413. 
  10. ↑ Liu, CJ; Zhang, SQ; Zhang, JS; Liang, Q; Li, DS (2011). «Chemical composition and antioxidant activity of essential oil from berries of Schisandra chinensis (Turcz.) Baill». Natural Product Research 26: 1. doi:10.1080/14786419.2011.636745. PMID 22103398. 
  11. ↑ Yang, Y; Xiao, Y; Liu, B; Fang, X; Yang, W; Xu, J (2011). «Comparison of headspace solid-phase microextraction with conventional extraction for the analysis of the volatile components in Melia azedarach». Talanta 86: 356–61. doi:10.1016/j.talanta.2011.09.028. PMID 22063551. 
  12. ↑ 12,0 12,1 Ho, CL; Liao, PC; Wang, EI; Su, YC (2011). «Composition and antifungal activities of the leaf essential oil of Neolitsea parvigemma from Taiwan». Natural Product Communications 6 (9): 1357–60. PMID 21941915. 
  13. ↑ Z. C. Gazim; A. C. Amorim; A. M. Hovell; C. M. Rezende; I. A. Nascimento; G. A. Ferreira; D. A. Cortez (2010). «Seasonal variation, chemical composition, and analgesic and antimicrobial activities of the essential oil from leaves of Tetradenia riparia (Hochst.) Codd in southern Brazil». Molecules 15 (8): 5509–5524. doi:10.3390/molecules15085509. PMID 20714310. 
  14. ↑ Tung, Y. T.; Huang, C. C.; Ho, S. T.; Kuo, Y. H.; Lin, C. C.; Lin, C. T.; Wu, J. H. (2011). «Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice». J. Agric. Food Chem. 59: 8117–8123. doi:10.1080/10412905.1999.9712005.