Β-Defensin 2
| β-Defensin | ||
|---|---|---|
| ||
| nach PDB 1E4Q | ||
| Andere Namen |
Beta-defensin 2, BD-2, hBD-2, Beta-defensin 4A, DEFB4A, DEFB-2, DEFB102, DEFB2, DEFB4, HBD-2, SAP1, | |
| Eigenschaften des menschlichen Proteins | ||
| Masse/Länge Primärstruktur | 64 Aminosäuren, 7.038 Da | |
| Bezeichner | ||
| Externe IDs | ||
| Vorkommen | ||
| Homologie-Familie | Hovergen | |
| Orthologe (Mensch) | ||
| Entrez | 1673 | |
| Ensembl | ENSG00000171711 | |
| UniProt | O15263 | |
| Refseq (mRNA) | NM_004942.3 | |
| Refseq (Protein) | NP_004933.1 | |
| PubMed-Suche | 1673
| |
β-Defensin 2 ist ein Protein aus der Gruppe der Defensine.[1]
Eigenschaften
Als Defensin ist β-Defensin ein antimikrobielles Peptid, das im Zuge der Immunantwort verstärkt gebildet wird. β-Defensin wird von Neutrophilen und Epithelzellen in der Haut und den Atemwegen gebildet. Es wirkt gegen Pilze der Gattung Candida und Gram-negative Bakterien.[2] β-Defensin bindet an CCR6 und löst in den CCR6-tragenden Zellen eine Chemotaxis aus. Unterhalb einer Konzentration von 2,4 mM liegt es als Monomer vor.[3]
Weblinks
Einzelnachweise
- ↑ J. Harder, J. Bartels, E. Christophers, J. M. Schröder: A peptide antibiotic from human skin. In: Nature. Band 387, Nummer 6636, Juni 1997, S. 861, doi:10.1038/43088, PMID 9202117.
- ↑ J. M. Schröder, J. Harder: Human beta-defensin-2. In: The international journal of biochemistry & cell biology. Band 31, Nummer 6, Juni 1999, S. 645–651, PMID 10404637.
- ↑ M. V. Sawai, H. P. Jia, L. Liu, V. Aseyev, J. M. Wiencek, P. B. McCray, T. Ganz, W. R. Kearney, B. F. Tack: The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment. In: Biochemistry. Band 40, Nummer 13, April 2001, S. 3810–3816, PMID 11300761.
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