Pathwaydesign

Pathwaydesign (auch metabolic engineering) ist eine Methode der Biochemie, bei der die Stoffwechselwege durch Proteindesign geändert werden. Das Pathwaydesign ist eine Form des rationalen Designs.

Eigenschaften

Beim Pathwaydesign werden durch Proteindesign bestehende Enzyme so verändert, dass auch das Substrat oder das Produkt geändert wird. Ebenso können durch Ergänzung des Genoms mit Genen von Enzymen neue Enzyme in einen Organismus eingeführt werden, bei Bakterien erfolgt dies meistens mit einem Plasmid. Dadurch können neue Stoffwechselwege in einem Organismus konstruiert werden, oder bestehende modifiziert, z. B. zur Vermeidung von Metabolitenschaden.[1] Durch modulares Vorgehen kann der Entwicklungsprozess beschleunigt werden.[2][3]

Selenzyme ist eine Onlinedatenbank zur Auswahl von Enzymen beim Pathwaydesign.[4][5]

Literatur

Einzelnachweise

  1. ↑ J. Sun, J. G. Jeffryes, C. S. Henry, S. D. Bruner, A. D. Hanson: Metabolite damage and repair in metabolic engineering design. In: Metabolic engineering. Band 44, November 2017, S. 150–159, doi:10.1016/j.ymben.2017.10.006, PMID 29030275.
  2. ↑ J. T. Boock, A. Gupta, K. L. Prather: Screening and modular design for metabolic pathway optimization. In: Current Opinion in Biotechnology. Band 36, Dezember 2015, S. 189–198, doi:10.1016/j.copbio.2015.08.013, PMID 26432992.
  3. ↑ H. Taniguchi, K. Okano, K. Honda: Modules formetabolic engineering: Pathway assembly for bio-based production of value-added chemicals. In: Synthetic and systems biotechnology. Band 2, Nummer 2, Juni 2017, S. 65–74, doi:10.1016/j.synbio.2017.06.002, PMID 29062963, PMC 5636945 (freier Volltext).
  4. ↑ P. Carbonell, J. Wong, N. Swainston, E. Takano, N. J. Turner, N. S. Scrutton, D. B. Kell, R. Breitling, J. L. Faulon, O. Stegle: Selenzyme: Enzyme selection tool for pathway design. In: Bioinformatics. [elektronische Veröffentlichung vor dem Druck] Februar 2018, doi:10.1093/bioinformatics/bty065, PMID 29425325.
  5. ↑ http://selenzyme.synbiochem.co.uk/

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